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Int J Cardiol 238:2230 Zhu L, Brown WC, Cai Q, Krust A, Chambon P, McGuinness OP, Stafford JM (2013) Estrogen treatment after ovariectomy protects against fatty liver and may improve pathway-selective insulin resistance

10.1111/j.1463-1326.2012.01557.x 64 JiL

Synthetic Methodologies and Optimization Industrial Synthesis Protocol The patented large-scale synthesis (CN101774934B) involves two stages: Acylation : Recrystallization : The reaction mechanism follows nucleophilic acyl substitution: Yield and Scalability Table 2 compares yields across experimental conditions